Name: Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce
Prep time: 10 min
Cook time: 15 min
Total time: 25 min
Cuisine: Southern
Ingredients: 1 lb rotini pasta; 1 lb boneless skinless chicken breast, diced; 2 tbsp Cajun seasoning; 2 tbsp olive oil; 3 cloves garlic, minced; 1 1/2 cups heavy cream; 1 1/2 cups Velveeta cheese, cubed; 1 cup shredded mozzarella cheese; 2 tbsp chopped parsley (optional, for garnish)

If you’re in the mood for bold Southern flavor wrapped in creamy decadence, this Cajun Chicken Rotini is calling your name. Each bite is an indulgent combination of tender, spice-rubbed chicken and velvety mozzarella Velveeta sauce, coating the rotini pasta in the kind of richness that only a comfort dish can deliver. Whether it’s a cozy family dinner or an impressive meal for guests, this dish never fails to satisfy.

The seared Cajun chicken brings just the right amount of smoky heat, while the creamy cheese sauce cools it down with smooth, savory notes. Add the twisty texture of rotini that holds onto all that cheesy goodness, and you’ve got yourself a meal worth repeating. Plus, it’s easy to make and comes together in one pan—yes, please!

Why You’ll Love This Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Comfort food classic with a spicy kick: It’s the perfect balance of heat, cheese, and pasta.
Quick and weeknight-friendly: Ready in under 30 minutes.
Velveeta + mozzarella = the ultimate creamy combo.
Perfect for meal prep: Holds up beautifully when reheated.
Family-approved: Even picky eaters love this cheesy, savory dish.

Preparation Phase & Tools to Use

Before you start cooking, make sure your kitchen is prepped with these essential tools. Each plays a key role in streamlining the process:

Non-stick skillet or cast iron pan: Perfect for searing the chicken to golden perfection and building flavor right in the pan.
Medium saucepan: Ideal for creating the creamy cheese sauce without sticking or burning.
Large pot: Needed to boil the rotini pasta until al dente.
Tongs and wooden spoon: Tongs help you flip chicken easily, while the spoon helps stir the sauce gently.
Colander: For quick and easy pasta draining.

Ingredients for the Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Rotini pasta: The ridges and spirals help hold onto the cheesy sauce.
Chicken breast: Boneless, skinless pieces provide a lean, protein-packed base.
Cajun seasoning: Adds that signature smoky-spicy flavor punch.
Olive oil: Helps sear the chicken for that irresistible golden crust.
Garlic: Fresh minced garlic boosts savory depth.
Heavy cream: The rich base for our luscious cheese sauce.
Velveeta cheese: Melts perfectly for that velvety texture.
Mozzarella cheese: Brings stretch and gooey goodness.
Parsley (optional): For garnish and a pop of freshness.

How To Make the Cajun Chicken Rotini in Creamy Mozzarella Velveeta Sauce

Step 1: Sear the Cajun Chicken

Season diced chicken breast with Cajun seasoning. Heat olive oil in a skillet over medium-high heat and sear the chicken until golden on all sides and fully cooked. Set aside.

Step 2: Boil the Rotini

In a large pot of salted boiling water, cook rotini pasta until al dente. Drain and set aside.

Step 3: Make the Creamy Sauce

In a medium saucepan, heat a touch of olive oil and sauté garlic until fragrant. Pour in heavy cream and bring to a gentle simmer. Stir in Velveeta and mozzarella cheeses until melted and smooth.

Step 4: Combine It All

Add cooked rotini to the cheese sauce and stir until fully coated. Then fold in the seared chicken or layer it on top.

Step 5: Garnish and Serve

Sprinkle with chopped parsley and serve hot. Dig into that creamy, spicy deliciousness!

Serving & Storing This Creamy Cajun Chicken Pasta

Serve this pasta hot, right out of the pan. It’s a hearty main dish that pairs perfectly with a light green salad or garlic bread.

Leftovers? Lucky you! Store in an airtight container for up to 3 days in the fridge. Reheat on the stovetop with a splash of cream or milk to bring back that creamy texture.

Freezing isn’t ideal due to the cheese sauce, but it can be done if necessary. Just note the texture may change slightly.

Frequently Asked Questions

Can I use a different type of pasta?

Absolutely! Penne, rigatoni, or shells all work well in place of rotini.

What if I don’t have Velveeta?

You can sub with extra mozzarella and a bit of cream cheese, though the texture won’t be quite as silky.

Is this dish spicy?

Mild to medium. Adjust the Cajun seasoning to your preference.

Can I use pre-cooked chicken?

Yes! Just warm it up in the skillet with seasoning to refresh the flavor before adding it to the dish.

How can I make it lighter?

Swap the heavy cream for half-and-half, and use reduced-fat cheese.

Want More Pasta Ideas with a Twist?

If you love this Cajun Chicken Rotini, you’ll probably enjoy these other cheesy and comforting pasta dishes:

Ultimate Cheesy Chicken Spaghetti for a baked Southern classic.
Garlic Butter Beef Cheesy Bowtie Pasta if you’re craving beefy, buttery richness.
Creamy Cajun Sausage Pasta for a spicy twist on your usual pasta night.
Beef and Rotini in Garlic Parmesan Sauce for savory simplicity done right.
One-Pot Smoky Chipotle Cheesy Chicken Pasta when you’re in the mood for bold and smoky flavors.

Save This Pin For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun seasoning or keep it mild? Did you sneak in extra cheese (no judgment)?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

Find more daily ideas and comfort meals on my Pinterest: Kitchen By Kate.