This Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce is everything comfort food should be — bold, creamy, cheesy, and absolutely irresistible. Think juicy chicken bites kissed with Cajun spice and seared in garlic butter until golden, paired with tender penne pasta coated in a luxurious parmesan cream sauce. It’s the kind of meal that turns a regular evening into a special one.

Perfect for family dinners or when you’re craving something satisfying, this dish strikes a delicious balance between smoky heat and creamy richness. Whether you’re a pasta lover, a garlic fiend, or someone who just appreciates a satisfying one-plate meal, this dish delivers big on flavor and even bigger on comfort.

Why You’ll Love This Cajun Garlic Butter Chicken Penne

It’s Flavor-Packed: Cajun seasoning brings a deep, smoky spice that pairs beautifully with creamy parmesan.
Fast and Easy: It comes together in under 40 minutes using everyday ingredients.
Family Favorite: Both kids and adults can’t resist the creamy, cheesy pasta with tender garlic butter chicken.
Customizable: Add mushrooms, spinach, or even a sprinkle of red chili flakes for a twist.
Restaurant Quality at Home: Tastes like something from a bistro but made in your own kitchen.

Preparation Phase & Tools to Use

Before diving into this creamy Cajun pasta, having the right tools ready can make cooking smoother and faster. Here’s what you’ll need:

Large Skillet or Sauté Pan: To sear the chicken and later combine all ingredients. A non-stick or stainless steel skillet works well.
Large Pot: For boiling the penne pasta until al dente.
Colander: For draining the pasta quickly and efficiently.
Wooden Spoon or Silicone Spatula: Perfect for stirring the sauce without scratching your pans.
Sharp Knife and Cutting Board: To dice chicken into even-sized pieces for consistent cooking.
Measuring Cups & Spoons: Ensures the perfect ratio of cream, parmesan, and seasonings.

A smooth workflow starts with organization, so prep all ingredients before you start cooking. This way, everything comes together seamlessly for a stress-free meal.

Ingredients for the Cajun Garlic Butter Chicken Penne

Chicken Breast or Thighs: Lean, juicy, and ideal for searing with Cajun seasoning.
Penne Pasta: The tube shape holds onto the creamy parmesan sauce beautifully.
Heavy Cream: Provides a rich, velvety texture to the sauce.
Fresh Garlic: A key player in the butter sauce; adds savory depth.
Cajun Seasoning: Brings that signature spicy, smoky flavor to the chicken.
Butter: Used to sear the chicken and develop deep garlic flavor.
Parmesan Cheese: The star of the sauce — it melts into the cream and creates a silky finish.
Olive Oil: Helps to brown the chicken evenly while adding flavor.
Parsley (fresh or dried): For garnish and a touch of herbal brightness.
Salt and Pepper: For balance and to enhance all the flavors.

How To Make the Cajun Garlic Butter Chicken Penne

Step 1: Prep the Chicken

Pat your chicken dry and cut it into bite-sized pieces. Toss it in olive oil, Cajun seasoning, salt, and pepper. Let it sit while you prepare other ingredients to absorb flavor.

Step 2: Sear the Chicken

Heat a large skillet with butter and olive oil over medium-high heat. Add chicken in a single layer and sear until golden and cooked through. Remove and set aside.

Step 3: Cook the Pasta

In a large pot, cook the penne pasta according to package directions. Reserve ½ cup of the pasta water before draining.

Step 4: Make the Parmesan Cream Sauce

In the same skillet, lower the heat and add more butter if needed. Sauté minced garlic for about 30 seconds until fragrant. Pour in the heavy cream and reserved pasta water. Stir and bring to a gentle simmer.

Step 5: Add Parmesan and Stir

Gradually whisk in grated parmesan cheese until the sauce is smooth and creamy. Season with additional Cajun spice if desired.

Step 6: Combine Everything

Return the chicken to the skillet and toss in the drained pasta. Stir well until every bite is coated in that luscious parmesan sauce.

Step 7: Garnish and Serve

Top with freshly chopped parsley and a sprinkle of extra parmesan. Serve warm and enjoy immediately.

How to Serve and Store This Cajun Chicken Penne

Serve this Cajun Garlic Butter Chicken Penne hot, directly from the skillet to plate, garnished with fresh parsley and extra grated parmesan. A side of garlic bread or a crisp green salad makes it a complete meal.

To store leftovers, let the pasta cool completely and transfer it to an airtight container. It will keep well in the refrigerator for up to 3 days. When reheating, add a splash of cream or milk to restore the sauce’s creaminess.

Frequently Asked Questions

What kind of Cajun seasoning should I use?

Any store-bought Cajun blend works, but check for salt levels to avoid over-seasoning. Homemade versions give you full control over the heat and saltiness.

Can I use a different pasta shape?

Absolutely! Penne holds the sauce well, but rotini, rigatoni, or fettuccine are great alternatives.

How can I make it spicier?

Add crushed red pepper flakes or a pinch of cayenne when seasoning the chicken or sauce.

Is this dish gluten-free?

It can be! Just use gluten-free pasta and double-check that your Cajun seasoning doesn’t contain wheat-based fillers.

Can I make it ahead of time?

Yes, but for best texture, store the pasta and sauce separately from the chicken and combine when reheating.

Can I add vegetables?

Absolutely. Mushrooms, spinach, or bell peppers can be sautéed and added to boost nutrition and texture.

Want More Chicken Pasta Ideas?

If you loved this Cajun Garlic Butter Chicken Penne, here are more flavor-packed pasta favorites to try next:

These dishes bring the same comforting richness with unique twists. Explore them and expand your pasta night lineup!

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And let me know in the comments how yours turned out. Did you go bold with extra Cajun heat? Maybe sneak in some spinach or mushrooms?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

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