If you’re craving bold Southern flair paired with comforting pasta, this Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is your new go-to. This dish brings together spicy Cajun-seasoned beef, rich tomato paste, and a luscious parmesan-based cheese sauce that clings to every strand of spaghetti like a savory hug. Imagine a skillet full of bubbling, melty goodness, crowned with fresh herbs and a golden cheese crust—this is indulgence at its best.

Whether you’re cooking for your family, hosting a dinner night, or simply spoiling yourself on a cozy evening, this recipe delivers the perfect blend of smoky heat, creamy texture, and cheesy satisfaction. It’s a one-skillet showstopper that’s easier than it looks and leaves everyone at the table asking for seconds.

Why You’ll Love This Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Flavor Explosion: The Cajun seasoning blends perfectly with the beef and creamy sauce for that signature Southern zest.
One-Skillet Wonder: Minimal cleanup means more time enjoying the food and less time scrubbing dishes.
Crowd-Pleaser: Ideal for potlucks, family dinners, or meal prep.
Cheese-Lovers Dream: A trio of cheeses—parmesan, mozzarella, and cheddar—melts into a dreamy sauce that wraps every bite in creamy delight.

Preparation Phase & Tools to Use

To make this cheesy Cajun masterpiece with ease, here are the essential tools you’ll need:

Cast-Iron Skillet or Oven-Safe Pan: Ensures even cooking and perfect bubbling cheese when broiled.
Large Pot: For boiling your spaghetti to al dente perfection.
Wooden Spoon or Silicone Spatula: Ideal for breaking up beef and stirring the sauce without damaging non-stick surfaces.
Box Grater: Freshly shredded cheese melts far better than pre-packaged blends.
Fine Mesh Strainer or Colander: To drain your pasta efficiently without losing noodles down the drain.

Each tool contributes to a smoother cooking experience—from sautéing and layering to broiling and serving. Don’t skip the skillet; it’s what gives this dish its crave-worthy texture.

Ingredients for the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Ground Beef: A hearty base that soaks up all the Cajun spices and makes the dish filling.
Cajun Seasoning: Brings bold, smoky flavor with just the right amount of kick.
Garlic & Onion: Essential for creating a savory foundation in the meat mixture.
Tomato Paste: Adds depth and balances out the creaminess with a touch of acidity.
Heavy Cream: Creates a luscious, rich texture in the cheese sauce.
Mozzarella Cheese: For that stretchy, gooey melt.
Sharp Cheddar Cheese: Adds tangy sharpness that cuts through the richness.
Parmesan Cheese: Brings nutty, salty depth and finishes the sauce perfectly.
Spaghetti Pasta: The vehicle that carries all that flavorful sauce.
Fresh Parsley: A bright garnish that brings color and a fresh finish.

How To Make the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Step 1: Cook the Pasta

Boil a large pot of salted water and cook the spaghetti until al dente. Drain and set aside.

Step 2: Brown the Beef

In a large cast-iron skillet, sauté chopped onion and garlic in a bit of oil. Add the ground beef and cook until browned. Drain excess fat.

Step 3: Season and Simmer

Stir in the Cajun seasoning and tomato paste. Let the mixture simmer for 3-4 minutes to blend the flavors.

Step 4: Build the Cream Sauce

Pour in heavy cream, stirring constantly. Gradually mix in mozzarella, cheddar, and parmesan until melted and the sauce thickens.

Step 5: Combine and Layer

Add the cooked spaghetti into the skillet. Toss until fully coated. Top with extra cheese and broil for 2-3 minutes until bubbly and golden.

Step 6: Garnish and Serve

Sprinkle fresh parsley on top and serve right from the skillet for that wow-factor presentation.

Serving and Storing This Creamy Cajun Beef Spaghetti

Serve this dish hot, straight from the skillet, paired with a crisp green salad or some warm garlic bread. It’s a full meal on its own but also shines as the centerpiece of a hearty family dinner.

Leftovers? Store in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stove with a splash of cream or milk to revive the creamy texture. It’s also freezer-friendly—just thaw overnight in the fridge before reheating.

Frequently Asked Questions

Can I use a different type of pasta?

Yes! Penne, fettuccine, or rotini work well too, especially if you like sauces to cling to the grooves.

Is this recipe spicy?

It has a medium Cajun kick. Adjust the heat by reducing or increasing the Cajun seasoning to your preference.

Can I substitute the beef?

Absolutely. Ground turkey, chicken, or plant-based alternatives can be used.

What if I don’t have a cast-iron skillet?

You can use any oven-safe skillet or transfer everything to a baking dish before broiling.

Can I make this ahead?

Yes. Prep the beef sauce and pasta separately, then combine and broil when ready to serve.

Want More Pasta Ideas with a Twist?

If you love this Creamy Cajun Beef Spaghetti, you’ll probably enjoy these comforting pasta dishes too:

Garlic Butter Beef Cheesy Bowtie Pasta for a buttery, cheesy beef explosion.
Million Dollar Ravioli Casserole when you’re craving layers of creamy pasta goodness.
Ultimate Cheesy Chicken Spaghetti for a poultry twist with loads of cheese.
Creamy Cajun Sausage Pasta if you want to double down on that Cajun flavor.
One-Pot Smoky Chipotle Cheesy Chicken Pasta for smoky heat in one cozy pot.

Save This Pin For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time: Kitchen By Kate on Pinterest

And let me know in the comments how yours turned out. Did you add more heat? Swap the cheese blend? I love hearing how others make these recipes their own.

Questions are always welcome—let’s help each other cook smarter and eat better!