Name: Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Cuisine: Cajun
Ingredients: 1 lb chicken breasts; 8 oz fettuccine pasta; 1 1/2 cups mozzarella cheese, shredded; 1 cup heavy cream; 3 cloves garlic, minced; 2 tbsp butter; 1 tbsp olive oil; 1 1/2 tbsp Cajun seasoning; Salt and pepper to taste; 2 tbsp fresh parsley, chopped

Prepare to fall in love with your new favorite comfort food. This Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is everything you crave in a single dish: juicy, spice-rubbed chicken seared to perfection, tender ribbons of fettuccine, and a rich, velvety sauce infused with garlic and gooey mozzarella. Every bite offers a creamy, cheesy, slightly spicy flavor explosion that’s completely irresistible.

Whether you’re whipping it up for a cozy dinner at home or aiming to impress guests, this pasta dish feels indulgent yet approachable. The Cajun spice blend brings bold flavor, while the garlic and mozzarella create that comforting melt-in-your-mouth finish that keeps everyone coming back for seconds.

Why You’ll Love This Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Flavor-Packed: A well-seasoned Cajun crust on the chicken ensures every bite is loaded with taste.
Velvety Cheese Sauce: Mozzarella and garlic combine into a creamy sauce that clings beautifully to every strand of fettuccine.
Perfect Texture Balance: The pasta is soft and tender, while the chicken provides a juicy, pan-seared bite.
Restaurant-Quality: It feels like something you’d order at a bistro but is incredibly easy to make at home.
Great for Gatherings: This meal is a showstopper and can be doubled to serve a crowd.

Preparation Phase & Tools to Use

Before diving into this dish, gather your essentials. Here’s what you’ll need and why it matters:

Large Non-Stick Skillet or Cast Iron Pan: Crucial for getting that perfectly seared, golden-brown crust on the Cajun chicken.
Large Pot: For boiling the fettuccine until it’s al dente. Generous water and a good pot make for even cooking.
Tongs or Spatula: To flip and move the chicken around in the pan without tearing the crust.
Box Grater or Cheese Shredder: Freshly shredded mozzarella melts more smoothly into the sauce than pre-shredded varieties.
Garlic Press or Fine Grater: Maximizes the flavor extraction from garlic, ensuring it blends seamlessly into the cheese sauce.
Whisk: Helps emulsify the sauce, preventing it from separating while keeping it luscious.

Ingredients for the Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Chicken Breasts: The heart of the dish, these provide a juicy and protein-rich base for the spicy Cajun flavor.
Fettuccine Pasta: Its wide, flat shape holds onto the creamy sauce perfectly.
Mozzarella Cheese: Delivers that essential creamy stretch and richness to the garlic sauce.
Heavy Cream: Creates the lush, silky body of the cheese sauce.
Fresh Garlic: Adds bold flavor and depth to the sauce, complementing the cheese and spice.
Butter: Helps sauté the garlic and adds richness to both the chicken and the sauce.
Olive Oil: Used for searing the chicken, helping achieve a crispy Cajun crust.
Cajun Seasoning: Provides a smoky, spicy kick that transforms the chicken into a flavor bomb.
Salt and Pepper: Essential for balancing flavors and enhancing both the chicken and sauce.
Fresh Parsley: A bright finishing touch that adds color and a pop of freshness.

How To Make the Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Step 1: Prep and Season the Chicken

Pat the chicken breasts dry and coat both sides generously with Cajun seasoning, salt, and pepper. Let the seasoning marinate for a few minutes while you prep other ingredients.

Step 2: Sear the Chicken

Heat olive oil in a cast iron skillet over medium-high heat. Sear the chicken breasts until golden and cooked through (about 5-7 minutes per side). Set aside to rest, then slice into strips.

Step 3: Boil the Fettuccine

While the chicken cooks, bring a large pot of salted water to a boil. Cook the fettuccine until al dente, then drain and reserve a bit of the pasta water.

Step 4: Make the Garlic Mozzarella Cheese Sauce

In the same skillet used for the chicken, lower the heat and add butter and minced garlic. Sauté until fragrant, then pour in the heavy cream. Stir well and slowly add shredded mozzarella, whisking until melted and smooth. Use a splash of pasta water if the sauce gets too thick.

Step 5: Combine Everything

Toss the drained fettuccine into the sauce and coat evenly. Add sliced Cajun chicken on top, garnish with chopped parsley, and give it one final toss so all the flavors meld.

Step 6: Serve Hot

Plate immediately with extra mozzarella on top if desired. The sauce is best enjoyed while hot and melty!

How to Serve and Store Creamy Cajun Chicken Fettuccine

This dish is best served hot and fresh straight from the stove. To create a restaurant-worthy presentation, pile the fettuccine into a nest shape, lay the sliced Cajun chicken on top, and finish with a sprinkle of parsley and extra melted mozzarella.

Pair it with a crisp green salad, garlic bread, or roasted vegetables for a complete meal. A cold glass of white wine or sweet tea balances the spice beautifully.

To store leftovers, place them in an airtight container and refrigerate for up to 3 days. When reheating, add a splash of cream or milk to revive the sauce’s silky texture. Avoid microwaving too long to prevent the chicken from drying out.

Frequently Asked Questions

What kind of Cajun seasoning works best?

Look for one with balanced spice and herbs. If making your own, blend paprika, garlic powder, onion powder, thyme, oregano, cayenne, and black pepper.

Can I use a different pasta?

Yes! Penne or linguine are great alternatives if fettuccine isn’t available. Just aim for a shape that grabs onto sauce.

Is it very spicy?

The heat level depends on your Cajun seasoning. For less spice, reduce cayenne or use a mild blend.

Can I use pre-shredded mozzarella?

While convenient, pre-shredded mozzarella contains anti-caking agents that prevent smooth melting. Freshly shredded is highly recommended.

What protein substitutes can I try?

Shrimp, sausage, or even crispy tofu can work wonderfully if you’re swapping out chicken.

How do I thicken the sauce more?

Simmer the sauce a little longer, or add more mozzarella gradually while stirring until desired consistency is reached.

Want More Pasta Ideas with a Kick?

If you loved this Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce, don’t stop here! Here are more bold and cheesy favorites from the Kitchen By Kate collection:

Garlic Butter Steak Tips with Cheesy Rigatoni is another rich, saucy dish packed with flavor.
Creamy Cajun Sausage Pasta doubles down on smoky spice with savory sausage.
Ultimate Cheesy Chicken Spaghetti is a weeknight favorite for creamy comfort.
Creamy One-Pan Marry Me Tortellini is perfect if you’re craving something romantic and indulgent.
Honey Pepper Chicken Mac and Cheese combines sweet heat with creamy pasta in a way you’ll crave often.

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And I’d love to hear how it went for you! Did you go bold with the Cajun seasoning or keep it mild? Did you sneak in extra cheese? Drop your tips and twists in the comments below.

We’re all about learning from each other here—so let’s cook, share, and grow together!