Twisted rotini pasta, juicy Cajun-spiced chicken, and melty strands of mozzarella all bathed in a luscious garlic cream sauce—this dish is the ultimate comfort food with a Southern kick. Every bite is a perfect mix of bold flavors and creamy richness, making it feel indulgent without being overcomplicated.

Whether you’re looking for a satisfying weeknight dinner or something to impress at your next casual get-together, this Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce delivers with its vibrant spice, tender chicken, and silky cheese sauce that clings to every spiral of pasta.

Why You’ll Love This Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Flavor-Packed: Cajun seasoning brings a smoky, spicy warmth that pairs perfectly with the cream and garlic.
Cheesy Goodness: The melted mozzarella adds stretchy, gooey comfort to every bite.
One Pan Potential: With a bit of planning, you can make this a one-pan wonder.
Perfect for Leftovers: Reheats beautifully without losing flavor or texture.
Restaurant Quality at Home: It looks and tastes gourmet, but it’s surprisingly simple.

Preparation Phase & Tools to Use

Getting organized is key to nailing this dish. Here are the tools you’ll want on hand:

Cast Iron Skillet or Heavy Pan: Helps you get that perfect sear on the chicken, locking in juices and flavor.
Large Pot: For boiling the rotini to al dente perfection.
Tongs or Silicone Spatula: For flipping and handling the chicken without tearing the crust.
Whisk: To keep the garlic mozzarella cream sauce silky smooth without clumps.
Colander: For quick draining of the pasta, saving time and mess.

These simple tools are the backbone of smooth prep and cooking, letting each part of the dish shine without the fuss.

Ingredients for the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Each ingredient in this dish plays a flavorful role:

Chicken Breasts: The star protein, juicy and tender when seared with Cajun spices.
Rotini Pasta: Perfect for trapping the creamy sauce in its spirals.
Mozzarella Cheese: Melts into dreamy strands and adds a comforting pull.
Heavy Cream: Creates the silky base for the garlic sauce.
Fresh Garlic: Adds bold, aromatic depth to the sauce.
Cajun Seasoning: Brings smoky heat and Southern flair.
Butter: Adds richness and helps bloom the garlic.
Olive Oil: For pan-searing the chicken to golden perfection.
Salt and Pepper: Essential to balance and amplify all the flavors.
Fresh Parsley (optional): For garnish and a touch of herbal freshness.

How To Make the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Rub Cajun seasoning generously onto both sides of the chicken breasts. Heat olive oil in a skillet over medium-high heat and sear the chicken for 4–5 minutes per side until golden and cooked through. Remove and let it rest before slicing.

Step 2: Boil the Rotini

While the chicken cooks, bring a pot of salted water to a boil. Add rotini and cook until al dente. Drain and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, reduce heat to medium and add butter. Sauté minced garlic until fragrant (about 30 seconds). Pour in the heavy cream, whisking constantly. Simmer for 3–4 minutes until slightly thickened.

Step 4: Add the Cheese

Stir in the mozzarella and continue whisking until melted and the sauce becomes creamy and smooth.

Step 5: Combine Everything

Add the drained rotini to the sauce and toss to coat. Slice the rested chicken and place it over the pasta. Spoon extra sauce over the top and sprinkle with parsley if using.

Serving and Storing Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Serve this dish hot right from the pan onto a warmed plate for the ultimate cozy comfort. Pair it with a crisp green salad or buttery garlic bread for a complete meal. The mozzarella will stretch beautifully while hot, so serve immediately for that melty effect!

For leftovers, store in an airtight container in the refrigerator for up to 3 days. Reheat on the stovetop with a splash of milk or cream to loosen the sauce. It also microwaves well in short bursts, stirred in between to maintain creaminess.

Freezing isn’t recommended due to the dairy content, which can cause the sauce to separate upon thawing.

Frequently Asked Questions

What if I don’t have Cajun seasoning?

You can make your own by mixing paprika, garlic powder, onion powder, oregano, thyme, cayenne, and black pepper. Or substitute with Creole seasoning for a similar vibe.

Can I use a different pasta shape?

Absolutely! Penne, rigatoni, or even fettuccine will work well—just make sure it holds onto the sauce.

Is there a lighter version of this recipe?

Yes, you can use half-and-half instead of heavy cream and part-skim mozzarella. The sauce won’t be as thick but still flavorful.

How spicy is this dish?

It has a warm kick, but it’s not overwhelming. Adjust the heat by reducing or increasing the amount of Cajun seasoning.

Can I make it vegetarian?

Swap the chicken with roasted cauliflower or mushrooms and use vegetable broth if thinning the sauce.

How do I keep the mozzarella from clumping?

Add it slowly, off the heat or on very low heat, and keep whisking to ensure smooth melting.

Want More Pasta Dinner Ideas with a Kick?

If you loved this Creamy Cajun Chicken Rotini, you’ll want to keep exploring these other savory pasta dishes that deliver bold flavors and satisfying comfort:

Each one adds its own unique twist—some with sweet heat, others with smoky garlic richness. They’re all easy weeknight winners.

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Let me know in the comments how your Cajun Chicken Rotini turned out. Did you tweak the spice level? Maybe add extra cheese (because why not)? I love hearing your kitchen spins and helping you level up your comfort food game.