Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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Golden, crispy Cajun-seasoned chicken paired with tender rotini pasta, all coated in a luscious mozzarella Alfredo sauce—this dish is comfort food with a bold, flavorful kick. Every forkful delivers a perfect balance of creamy, cheesy indulgence and that signature Cajun spice that keeps you coming back for more. The chicken is pan-seared to lock in juices, while the sauce clings to every twist of rotini for maximum flavor in every bite.

Whether you’re making it for a weeknight family dinner or impressing guests at a casual gathering, this recipe is both satisfying and elegant. The combination of textures—crispy chicken, silky sauce, and al dente pasta—makes it a showstopper, while the Cajun seasoning adds a warm, smoky depth that’s irresistible.

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Why You’ll Love This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

If you love comfort food but crave bold, layered flavors, this dish is a perfect match. It takes the richness of Alfredo pasta and amplifies it with Cajun spices for a lively twist. The mozzarella brings that extra stretch and creaminess, while the rotini shape ensures the sauce coats every nook and cranny. Plus, it’s versatile enough to adapt—swap in shrimp, add veggies, or make it extra spicy to suit your taste.

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Preparation Phase & Tools to Use

To make this recipe seamless and enjoyable, having the right tools matters:

• Large Skillet – For searing the chicken to golden perfection while keeping it juicy.
• Medium Saucepan – Ideal for simmering the mozzarella Alfredo sauce without scorching.
• Large Pot – To boil the rotini pasta to al dente, giving it the perfect bite.
• Tongs – Handy for flipping the chicken without losing the crispy coating.
• Whisk – Essential for blending the Alfredo sauce until it’s silky smooth.
• Cutting Board & Chef’s Knife – For prepping the chicken and any optional veggies.

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Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

• Chicken Breasts – The protein base, seasoned for bold flavor.
• Cajun Seasoning – Brings smoky heat and depth to the chicken.
• Rotini Pasta – Perfect for holding onto creamy sauce in every bite.
• Mozzarella Cheese – Melts into the Alfredo sauce for stretch and creaminess.
• Heavy Cream – Creates the luscious, velvety sauce texture.
• Parmesan Cheese – Adds nutty, savory depth to balance the richness.
• Butter – Forms the base for the Alfredo sauce, adding flavor and silkiness.
• Garlic – Provides aromatic warmth to the sauce.
• Salt & Pepper – For seasoning and balancing flavors.

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How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Season and Sear the Chicken

Coat chicken breasts evenly with Cajun seasoning. Heat a large skillet with a drizzle of oil and sear the chicken until golden brown on both sides and fully cooked through. Remove and let rest before slicing.

Step 2: Cook the Pasta

In a large pot of salted boiling water, cook the rotini pasta until al dente. Drain and set aside, reserving a small cup of pasta water.

Step 3: Prepare the Alfredo Base

In a medium saucepan, melt butter over medium heat. Add minced garlic and sauté until fragrant. Stir in heavy cream and bring to a gentle simmer.

Step 4: Add the Cheese

Lower the heat and whisk in Parmesan and mozzarella cheese until smooth and creamy. Adjust consistency with reserved pasta water if needed.

Step 5: Combine Pasta and Sauce

Add cooked rotini to the sauce and toss to coat evenly. Season with salt and pepper to taste.

Step 6: Assemble and Serve

Slice the rested chicken and arrange over the creamy rotini. Sprinkle with extra Parmesan or fresh parsley for garnish.

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Serving and Storing This Recipe

Serve immediately for the best flavor and texture, pairing it with garlic bread or a fresh green salad. Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stove with a splash of cream or milk to keep the sauce smooth.

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Frequently Asked Questions

Can I use pre-cooked chicken?

Yes, but you’ll miss the flavor from searing with Cajun seasoning. If using pre-cooked chicken, warm it in the sauce.

Can I make this dish spicier?

Absolutely! Increase the Cajun seasoning or add a pinch of cayenne pepper.

What other cheeses can I use?

Fontina, provolone, or a sharp white cheddar can work for different flavor profiles.

Can I use a different pasta shape?

Yes, penne, fusilli, or farfalle will work, but rotini holds the sauce exceptionally well.

Is this dish freezer-friendly?

It’s best enjoyed fresh, as cream sauces can separate when thawed, but you can freeze it if needed.

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Want More Pasta Ideas?

If you love this creamy Cajun chicken rotini, you’ll probably enjoy these other favorites:

• One-Pot Smoky Chipotle Cheesy Chicken Pasta
• Garlic Butter Chicken Balls with Creamy Parmesan Pasta
• Pepper Parmesan Chicken Penne
• Creamy Cajun Sausage Pasta

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Save This Pin For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun spice? Did you try it with shrimp instead of chicken?

I love hearing how others make these recipes their own. For more delicious creations, visit my Pinterest Kitchen By Kate.

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