This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is the perfect comfort meal when you’re craving bold flavors and creamy indulgence. Each bite delivers a fiery Cajun kick mellowed by a luxuriously rich mozzarella-infused garlic cream sauce. The pan-seared chicken, seasoned to perfection, sits atop a bed of spaghetti that’s coated in silky, cheesy goodness.

Perfect for cozy weeknights or an impressive weekend dinner, this dish brings together Southern spice and Italian comfort. Whether you’re a pasta enthusiast or someone who just loves a saucy, satisfying chicken dish, this recipe delivers in flavor, texture, and satisfaction. It’s quick enough for weeknights yet indulgent enough to make anyone feel spoiled.

Why You’ll Love This Creamy Cajun Chicken Spaghetti

Bold Cajun Flavors: The spice blend adds a smoky, slightly spicy depth that balances beautifully with the creamy sauce.
Velvety Garlic Mozzarella Sauce: Rich, creamy, and stretchy from the melted mozzarella — it’s the kind of sauce you want to savor.
Hearty & Satisfying: A full meal with protein, carbs, and plenty of flavor in every forkful.
Weeknight Friendly: It looks fancy, but it comes together in under 40 minutes.

Preparation Phase & Tools to Use

To bring out the best in this decadent dish, make sure you have the following tools ready:

Cast Iron or Heavy Skillet: This ensures a beautiful sear on the chicken, locking in flavor with crispy, golden edges.
Medium Saucepan: Perfect for crafting the garlic mozzarella sauce with gentle, even heating.
Large Pot: For boiling the spaghetti to al dente perfection.
Whisk: Essential for ensuring the sauce stays smooth and lump-free.
Tongs or Pasta Spoon: Helps in coating the spaghetti thoroughly in sauce without breaking the pasta.

Each tool is chosen to maximize ease and texture—you don’t want to skimp on the creamy melt or that savory seared crust. Set up your space ahead of time, and you’ll fly through this cooking experience like a pro.

Ingredients for the Creamy Cajun Chicken Spaghetti

Chicken Breasts – The star protein, seasoned and seared for maximum flavor.
Spaghetti – Holds the creamy sauce and ties everything together.
Mozzarella Cheese – Adds stretch and richness to the garlic sauce.
Heavy Cream – Creates the base for the silky, decadent sauce.
Fresh Garlic – Intensifies the aroma and gives the sauce a bold kick.
Butter – For sautéing garlic and adding flavor depth.
Olive Oil – Helps sear the chicken evenly without burning.
Cajun Seasoning – Delivers spice, smokiness, and color.
Salt and Pepper – For balancing all the bold flavors.
Parsley (optional) – Adds a fresh pop of color and brightness.

How To Make the Creamy Cajun Chicken Spaghetti

Step 1: Season and Sear the Chicken

Pat dry your chicken breasts and generously rub them with Cajun seasoning. Heat olive oil in a cast iron skillet over medium-high heat, then sear the chicken for 5–7 minutes per side until golden and fully cooked. Set aside and let it rest.

Step 2: Cook the Spaghetti

While the chicken cooks, boil your spaghetti in salted water until just al dente. Drain and set aside, saving 1/2 cup of the pasta water.

Step 3: Make the Garlic Mozzarella Sauce

In a medium saucepan, melt butter over medium heat. Add minced garlic and sauté until fragrant. Pour in heavy cream and whisk well. Stir in shredded mozzarella until fully melted and silky. Season with salt, pepper, and parsley.

Step 4: Combine Pasta and Sauce

Toss the cooked spaghetti into the garlic mozzarella sauce, adding a splash of reserved pasta water to loosen if needed. Use tongs to mix everything until the pasta is coated beautifully.

Step 5: Slice and Serve

Slice the rested Cajun chicken and serve it over the cheesy spaghetti. Spoon extra sauce over the top and garnish with more parsley.

How to Serve and Store Your Cajun Chicken Spaghetti

Serve this dish hot and fresh, with a simple side like roasted veggies or a crisp green salad. Garlic bread makes an excellent companion to mop up the luscious sauce.

If you have leftovers (rare, but lucky!), store them in an airtight container in the fridge for up to 3 days. Reheat gently on the stovetop with a splash of milk or cream to bring back the creaminess.

Frequently Asked Questions

How spicy is this dish?

It has a mild to medium spice from the Cajun seasoning. You can adjust heat by adding or omitting red pepper flakes.

Can I use a different type of pasta?

Absolutely! Fettuccine, penne, or linguine work well if you prefer another pasta shape.

What kind of Cajun seasoning should I use?

Any store-bought Cajun blend works, or you can make your own with paprika, garlic powder, cayenne, oregano, and thyme.

Can I make this dish ahead of time?

You can prep the sauce and chicken in advance, but for best results, combine with fresh pasta just before serving.

Can I make it lighter?

Yes! Use half-and-half instead of heavy cream and reduce the cheese slightly.

Want More Chicken Pasta Ideas?

If you love this Creamy Cajun Chicken Spaghetti, you’ll definitely want to try these mouthwatering options:

Golden Crispy Chicken with Parmesan Mushroom Sauce for a rich, earthy twist.
Ultimate Cheesy Chicken Spaghetti if you’re into baked cheesy goodness.
Garlic Butter Chicken Balls with Creamy Parmesan Pasta for bite-sized comfort.
One Pot Creamy Tuscan Chicken Pasta for sun-dried tomato bliss.
Cajun Ranch Shrimp and Sausage Pasta Skillet when you’re in the mood for surf and turf.

Save This Pin For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time: Kitchen By Kate on Pinterest

And let me know in the comments how yours turned out! Did you dial up the spice or keep it creamy and classic? Did you add a veggie twist or extra cheese?

I love hearing how these recipes come to life in your kitchen. Ask questions, share tips, or just drop a “yum”—we’re all in this for the flavor!