Craving a bold, creamy comfort meal that hits all the right notes? This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is everything your taste buds dream of on a busy weeknight or indulgent weekend dinner. Juicy, seasoned chicken meets a creamy, cheesy Alfredo sauce that coats every twist of rotini pasta, all with a kick of Cajun spice to keep things interesting.

The crispy, golden sear on the chicken gives this dish restaurant-level satisfaction at home, while the velvety mozzarella Alfredo sauce balances heat and richness in every bite. It’s the kind of meal that gets people around the table fast and leaves them asking for seconds.

Why You’ll Love This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Flavor Explosion: The Cajun spices create a smoky, spicy profile that pairs perfectly with the creamy mozzarella Alfredo sauce.
Family-Friendly: It’s spicy enough to be exciting, but mellowed by the sauce to please all palates.
Hearty & Satisfying: Protein-rich chicken, hearty pasta, and cheesy goodness make this a filling one-plate dinner.
Easy to Make: Simple ingredients, one skillet for the chicken, and a quick sauce make this doable any night of the week.

Preparation Phase & Tools to Use

Essential Tools and Equipment:

Cast Iron Skillet or Nonstick Frying Pan: For searing the Cajun chicken to golden perfection. Cast iron retains heat well and helps develop that delicious crust.
Large Saucepan or Dutch Oven: Perfect for boiling rotini pasta evenly and with enough room to avoid sticking.
Saucepan: Used to make the mozzarella Alfredo sauce smooth and creamy without scorching.
Whisk: Key for stirring the Alfredo sauce to avoid lumps and create that silky finish.
Tongs and Cutting Board: For flipping and slicing the chicken into perfect bite-sized strips.

Each tool serves a purpose that enhances the final flavor and texture of the dish. Trust these basics to help everything come together smoothly.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Boneless Skinless Chicken Breasts – Lean protein that crisps beautifully when seared with Cajun seasoning.
Rotini Pasta – Its twisted shape holds onto the creamy Alfredo sauce in every bite.
Mozzarella Cheese – Adds creamy, stretchy richness to the Alfredo sauce.
Heavy Cream – The base of the Alfredo, delivering that rich, velvety texture.
Butter – Helps create the creamy Alfredo foundation while adding a hint of richness.
Garlic (Minced) – Infuses the sauce with savory depth.
Cajun Seasoning – Brings smoky heat that defines the flavor of the dish.
Olive Oil – Used for cooking the chicken, adds richness and helps with browning.
Parsley (optional) – For garnish and a pop of color and freshness.
Salt & Pepper – Essential for seasoning to taste.

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Season and Sear the Chicken

Coat the chicken breasts with Cajun seasoning, pressing it into the meat. Heat olive oil in a skillet over medium-high and sear the chicken on both sides until golden and cooked through (about 4-5 minutes per side). Remove and let rest before slicing.

Step 2: Cook the Pasta

Boil a large pot of salted water and cook the rotini according to the package instructions until al dente. Drain and set aside.

Step 3: Make the Mozzarella Alfredo Sauce

In a saucepan, melt butter over medium heat. Add the minced garlic and sauté until fragrant. Pour in the heavy cream and bring to a gentle simmer. Stir in the shredded mozzarella and whisk until fully melted and smooth. Season with salt and pepper to taste.

Step 4: Combine Pasta and Sauce

Add the cooked rotini into the Alfredo sauce and toss until every piece is thoroughly coated. Keep the heat on low to let the flavors blend.

Step 5: Slice and Serve the Chicken

Slice the rested Cajun chicken into strips and arrange over a bed of the creamy twisted pasta. Garnish with chopped parsley if desired, and serve immediately while hot.

How to Serve and Store This Creamy Cajun Chicken Pasta

Serving:
Serve this dish immediately while it’s hot and creamy. Plate the pasta first, then top with the sliced Cajun chicken. Garnish with a sprinkle of parsley and a light dusting of extra mozzarella if desired. Pair it with garlic bread or a crisp Caesar salad for a full meal.

Storing:
Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, add a splash of cream or milk and warm over medium heat on the stovetop or microwave until heated through. The sauce will thicken as it sits, so loosening it up helps maintain the creamy texture.

Frequently Asked Questions

Can I use a different pasta shape?

Absolutely! Penne, fusilli, or even fettuccine work well. Just choose a shape that holds sauce.

What if I don’t have Cajun seasoning?

You can make your own with paprika, garlic powder, onion powder, cayenne, thyme, and oregano. Or sub with blackened seasoning for a similar kick.

Can I make it less spicy?

Yes. Just reduce the Cajun seasoning amount or use a mild version. You can also balance heat with extra cream or cheese.

Can this be made ahead of time?

The components can be prepped in advance, but for best results, combine everything fresh so the sauce doesn’t thicken or separate.

What proteins can I substitute for chicken?

Shrimp, turkey cutlets, or even tofu for a vegetarian version all work great in place of chicken.

How do I avoid grainy Alfredo sauce?

Always melt cheese slowly on low heat, and whisk constantly. Don’t let it boil—a gentle simmer is key.

Want More Creamy Pasta Ideas?

If this bold and creamy pasta recipe is your kind of meal, you’ll love diving into these other indulgent favorites:

Save This Pin For Later

📌 Save this recipe to your Pinterest comfort food board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you swap the chicken for shrimp? Add some heat with extra cayenne? I love seeing your personal twists!

You can also follow along on Pinterest – Kitchen By Kate for daily recipe inspiration and kitchen tips.