This Cajun Garlic Chicken Tortellini in Three-Cheese Cream is comfort food with a fiery, cheesy twist that hits every craving. Tender tortellini stuffed with cheese soaks up a rich, velvety sauce made from not one, but three kinds of cheese. Paired with juicy, spiced Cajun grilled chicken and flecked with herbs and red pepper flakes, this dish is a bold burst of Southern flavor with every forkful.

The magic lies in the balance: creamy richness without heaviness, Cajun spice with just the right kick, and cheese that coats every bite without overpowering. Whether you’re impressing guests or simply craving a cozy night-in dinner, this recipe brings restaurant-level flair right to your home kitchen.

Why You’ll Love This Cajun Garlic Chicken Tortellini in Three-Cheese Cream

Restaurant-worthy flavor: The Cajun-spiced chicken and decadent cheese sauce make it feel indulgent and gourmet.
Quick and satisfying: With minimal prep and under 40 minutes to the table, it’s a weeknight winner.
Customizable heat: Adjust the Cajun seasoning and pepper flakes to match your spice level.
Comfort food with a twist: Cheese lovers and spice lovers unite for this ultra-creamy, ultra-satisfying combo.

Preparation Phase & Tools to Use

Before diving into this flavorful dish, having the right tools makes a major difference:

Cast iron skillet or grill pan: Essential for getting that smoky char on the chicken while sealing in the juices.
Large saucepan or deep skillet: Perfect for simmering the cheese sauce and gently tossing in the tortellini.
Tongs or spatula: Helps flip the chicken evenly without losing those golden-brown sear marks.
Whisk: To create a silky, lump-free cheese sauce that clings beautifully to the pasta.
Cutting board and sharp knife: For slicing the Cajun chicken into clean, picture-perfect strips.

Ingredients for the Cajun Garlic Chicken Tortellini in Three-Cheese Cream

Chicken breasts: Boneless and skinless, they soak up the Cajun seasoning perfectly and add juicy protein to balance the rich pasta.
Cheese tortellini: These little pillows of pasta are filled with creamy cheese and serve as the perfect vehicle for the sauce.
Heavy cream: Forms the lush, silky base of the three-cheese sauce.
Parmesan cheese: Adds sharpness and depth, melting smoothly into the cream.
Mozzarella cheese: Provides gooey, stretchy texture and mild flavor.
Cream cheese: Gives the sauce body and a rich tang that balances the spice.
Fresh garlic: Boosts the flavor and enhances the Cajun seasoning.
Cajun seasoning: The key spice blend for coating the chicken, delivering that signature Southern kick.
Butter: Helps sear the chicken and add richness to the sauce.
Fresh parsley and red pepper flakes: For garnish and a touch of heat.

How To Make the Cajun Garlic Chicken Tortellini in Three-Cheese Cream

Step 1: Season and Sear the Chicken

Generously rub the chicken breasts with Cajun seasoning. Heat a skillet with a mix of butter and oil and sear the chicken on both sides until fully cooked and golden brown. Let rest before slicing.

Step 2: Boil the Tortellini

Cook the tortellini according to package instructions until al dente. Drain and set aside, saving some pasta water.

Step 3: Build the Cheese Sauce

In the same pan, melt butter and sauté garlic until fragrant. Pour in the heavy cream and bring to a simmer. Slowly whisk in cream cheese, Parmesan, and mozzarella. Stir until completely melted and smooth. Add a splash of reserved pasta water if needed for thinning.

Step 4: Toss and Combine

Add the cooked tortellini into the sauce and toss to coat. Let everything simmer together for 2-3 minutes so the pasta absorbs the flavors.

Step 5: Assemble and Serve

Slice the Cajun chicken and lay it over the cheesy tortellini. Garnish with chopped parsley and red pepper flakes. Serve warm and enjoy every creamy, spicy bite!

How to Serve and Store Cajun Garlic Chicken Tortellini

Serve this dish hot and fresh, with the chicken slices neatly arranged over the cheesy tortellini for maximum visual and textural appeal. A light sprinkle of chopped parsley and a dash of red pepper flakes take it from great to gourmet. Pair with a simple green salad or garlic bread to round out your plate.

To store, transfer leftovers to an airtight container and refrigerate for up to 3 days. When reheating, use a splash of milk or cream to loosen the sauce and stir gently over low heat. This dish is best enjoyed fresh, but it also makes a fantastic lunch the next day.

Frequently Asked Questions

How spicy is this dish?

The Cajun seasoning brings a noticeable kick, but it’s balanced by the creamy cheese sauce. You can dial it up or down by adjusting the seasoning or omitting red pepper flakes.

Can I use frozen tortellini?

Yes! Frozen cheese tortellini works perfectly. Just follow the package instructions for boiling and be sure not to overcook them.

What can I substitute for Cajun seasoning?

If you don’t have Cajun seasoning, you can make your own with paprika, garlic powder, onion powder, oregano, thyme, cayenne, and black pepper. Or use Creole seasoning for a similar flavor.

Is this recipe gluten-free?

Not as written, since traditional tortellini contains wheat. But you can use a gluten-free tortellini alternative and ensure your Cajun spice mix is gluten-free too.

Can I prep this ahead?

You can cook the chicken and even make the sauce in advance. Reheat gently and combine everything before serving to keep the tortellini from becoming mushy.